Marc said:Maybe its like discussing who is the better footballer, ROnaldinho or Henry? There is no right or wrong answer![]()
haarewin said:i think i can link the abstract. let me
Abstract
We compared the neuroprotective and metabolic effects of chronic treatment with ionotropic or metabotropic glutamate receptor antagonists, in rats bearing a unilateral nigrostriatal lesion induced by 6-hydroxydopamine (6-OHDA). The ionotropic, N-methyl-d-aspartate receptor antagonist MK-801 increased cell survival in the substantia nigra pars compacta (SNc) and corrected the metabolic hyperactivity (increased cytochrome oxidase activity) of the ipsilateral substantia nigra pars reticulata (SNr) associated with the lesion, but showed no effects on the 6-OHDA-induced hyperactivity of the subthalamic nucleus (STN). Significant—although less pronounced—protection of SNc neurons was also observed following treatment with the metabotropic glutamate receptor (mGluR5) antagonist 2-methyl-6-(phenylehtynyl)-pyridine (MPEP). As opposed to MK-801, MPEP abolished the STN metabolic hyperactivity associated with the nigrostriatal lesion, without affecting SNr activity. Specific modulation of STN hyperactivity obtained with mGluR5 blockade may, therefore, open interesting perspectives for the use of this class of compounds in the treatment of Parkinson's disease.
Marc said:Aww they took it down and banned me :<
Ballard said:But is that actually aspartame? It seems to be some compound and is spelt differently or is that just scientific talk?
Sparx said:my opinion is right i can show loads of Ronaldinho fan websites that prove he is the best
haarewin said:NMDA is a glutaminergic neurotransmitter, and is formed from aspartic acid (aspartate), which is a metabolite of aspartame.
Ballard said:So in the metabolising process of aspartame this would be produced? or only under lab conditions?
p.s thanks for the info
Darzil said:Personally, I've been avoiding Aspartame/Nutrasweet since the concerns in the early 90's. At that time, miscarriages and still births were pretty much the main concern, though.
Anyone else old enough to remember that at the same time it couldn't be sold in the US, that Nutrasweet appeared in TV adverts in the UK, with saturation advertising? First time I'd ever seen what was only an ingredient pushed in that way.
There was a fair amount of money thrown at getting us all to use it.
Darzil