F8 only works close range (and usually sticks on 2 targets). GL playing CC class w/o mouse

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Oh and anyone who leaves it bound in that useless part of the keyboard is a muppet

, mine is E.
I play in a FPS way. Anything non quickbar bound to left of keyboard, movement, bindable / commands, etc. RDFG layout.
Everything else is mouse, looking, targeting, qbar, spells. Ive started moving qbar to below centre to minimise movement. Playing melee I tend to use keys when I need to do backup styles because its slightly quicker than mouse.